.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
This randomized, placebo-controlled trial evaluated whether personalizing accelerated intermittent theta-burst stimulation (aiTBS) using resting-state fMRI connectivity and EEG-derived stimulation frequency could improve outcomes in treatment-resistant depression. Fifty-one patients were randomized to fMRI-connectivity-guided aiTBS, combined fMRI/EEG-guided aiTBS, or sham; 43 completed the protocol. Participants received 10 sessions daily for 5 consecutive days. Neither active treatment significantly outperformed sham for the primary MADRS outcome at 1 week or secondary DARS anhedonia scores. Response and remission rates also did not differ significantly between groups. The findings suggest that individualized targeting and frequency selection did not provide additional antidepressant benefit over sham in this trial, highlighting the need for further adequately powered studies.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
This randomized, placebo-controlled trial evaluated whether personalizing accelerated intermittent theta-burst stimulation (aiTBS) using resting-state fMRI connectivity and EEG-derived stimulation frequency could improve outcomes in treatment-resistant depression. Fifty-one patients were randomized to fMRI-connectivity-guided aiTBS, combined fMRI/EEG-guided aiTBS, or sham; 43 completed the protocol. Participants received 10 sessions daily for 5 consecutive days. Neither active treatment significantly outperformed sham for the primary MADRS outcome at 1 week or secondary DARS anhedonia scores. Response and remission rates also did not differ significantly between groups. The findings suggest that individualized targeting and frequency selection did not provide additional antidepressant benefit over sham in this trial, highlighting the need for further adequately powered studies.
4 weeks back
Explore the therapeutic promise of TLR7 and TLR8 inhibitors in managing systemic lupus erythematosus and monogenic autoimmune diseases. Learn how targeting endolysosomal single-stranded RNA sensing and regulatory checkpoints like UNC93B1 and PLD4 offers precision treatment without broad immunosuppression.
Yesterday
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
3 weeks back
Abdominal aortic aneurysm rupture remains a catastrophic vascular emergency. Groundbreaking research reveals that USP53 accelerates aneurysm progression by reprogramming smooth muscle cell metabolism toward aerobic glycolysis, highlighting a promising target beyond conventional diameter-based surveillance.
2 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
Yesterday
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
2 days back
