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The KEYNOTE-826 trial demonstrated that adding pembrolizumab to platinum-based chemotherapy, with or without bevacizumab, improved progression-free survival and overall survival in persistent, recurrent or metastatic cervical cancer. The findings established immune-checkpoint inhibition as an important first-line treatment option for many patients with advanced disease. For gynecologic oncology, biomarker assessment and careful toxicity monitoring are increasingly integrated into treatment planning. Immune-related adverse events can affect endocrine, hepatic, pulmonary and gastrointestinal systems and may require treatment interruption or corticosteroids. The study underscores the shift from chemotherapy-only strategies toward combinations that target both tumor proliferation and antitumor immunity.
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The KEYNOTE-826 trial demonstrated that adding pembrolizumab to platinum-based chemotherapy, with or without bevacizumab, improved progression-free survival and overall survival in persistent, recurrent or metastatic cervical cancer. The findings established immune-checkpoint inhibition as an important first-line treatment option for many patients with advanced disease. For gynecologic oncology, biomarker assessment and careful toxicity monitoring are increasingly integrated into treatment planning. Immune-related adverse events can affect endocrine, hepatic, pulmonary and gastrointestinal systems and may require treatment interruption or corticosteroids. The study underscores the shift from chemotherapy-only strategies toward combinations that target both tumor proliferation and antitumor immunity.
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