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Large pooled analyses and cohort studies show that combined oral contraceptive use is associated with a substantial reduction in epithelial ovarian cancer risk, with protection persisting for years after discontinuation. The protective effect increases with longer duration of use. For gynecologists, counseling should balance this benefit against the individual's contraceptive needs and the known risks and benefits of hormonal contraception. The finding is especially relevant for women with elevated hereditary risk, although oral contraceptives do not replace genetic counseling or risk-reducing surgery when those are indicated.
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Large pooled analyses and cohort studies show that combined oral contraceptive use is associated with a substantial reduction in epithelial ovarian cancer risk, with protection persisting for years after discontinuation. The protective effect increases with longer duration of use. For gynecologists, counseling should balance this benefit against the individual's contraceptive needs and the known risks and benefits of hormonal contraception. The finding is especially relevant for women with elevated hereditary risk, although oral contraceptives do not replace genetic counseling or risk-reducing surgery when those are indicated.
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