.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
MR CLEAN was the pivotal randomized trial that established the efficacy of intra-arterial treatment for acute ischemic stroke caused by proximal anterior-circulation arterial occlusion. Five hundred patients were randomized to usual care with or without intravenous alteplase plus intra-arterial treatment. The intervention group had a better overall distribution of functional outcomes at 90 days, with a clinically important increase in functional independence. There was no significant increase in mortality or symptomatic intracerebral haemorrhage. The trial was transformative because it showed that modern endovascular treatment using retrievable stents could improve patient outcomes when added to standard medical therapy. For HCPs, MR CLEAN also highlights the importance of patient selection and workflow: vascular imaging should identify eligible large-vessel occlusion quickly, and treatment should be delivered without unnecessary delay. The study provides the foundation for the larger evidence base that later extended thrombectomy into the late window and, more recently, into selected large-core strokes. Its relevance to IANCON's vascular neurology and thrombectomy sessions remains substantial.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
MR CLEAN was the pivotal randomized trial that established the efficacy of intra-arterial treatment for acute ischemic stroke caused by proximal anterior-circulation arterial occlusion. Five hundred patients were randomized to usual care with or without intravenous alteplase plus intra-arterial treatment. The intervention group had a better overall distribution of functional outcomes at 90 days, with a clinically important increase in functional independence. There was no significant increase in mortality or symptomatic intracerebral haemorrhage. The trial was transformative because it showed that modern endovascular treatment using retrievable stents could improve patient outcomes when added to standard medical therapy. For HCPs, MR CLEAN also highlights the importance of patient selection and workflow: vascular imaging should identify eligible large-vessel occlusion quickly, and treatment should be delivered without unnecessary delay. The study provides the foundation for the larger evidence base that later extended thrombectomy into the late window and, more recently, into selected large-core strokes. Its relevance to IANCON's vascular neurology and thrombectomy sessions remains substantial.
Today
The phase 3 ACACIA-HCM trial reveals that aficamten improves cardiac structure, diastolic relaxation, functional capacity, and symptom burden in symptomatic nonobstructive hypertrophic cardiomyopathy, marking a major milestone in targeted myosin inhibition.
6 days back
A clinical study shows that automated breast ultrasound paired with artificial intelligence accurately classifies BIRADS 3-4 lesions, reaching 95% sensitivity and 79% specificity. This diagnostic advance promises to reduce unnecessary core needle biopsies and refine clinical workflows in breast imaging.
3 weeks back
Researchers have engineered freestanding hierarchical-porous BCZT thin films that resist cracking and enhance ultrasonic energy harvesting in soft tissue. Achieving high piezoelectric output and acoustic matching, this lead-free material offers transformative potential for implantable bioelectronics.
6 days back
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
3 weeks back
A breakthrough study identifies the Klotho/PKCα/CUX1/SPARC/TGFβ-RII axis as a critical driver of podocyte mitochondrial injury and ferroptosis in diabetic kidney disease, unveiling promising molecular targets to halt renal disease progression.
6 days back
