.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
MR CLEAN was the pivotal randomized trial that established the efficacy of intra-arterial treatment for acute ischemic stroke caused by proximal anterior-circulation arterial occlusion. Five hundred patients were randomized to usual care with or without intravenous alteplase plus intra-arterial treatment. The intervention group had a better overall distribution of functional outcomes at 90 days, with a clinically important increase in functional independence. There was no significant increase in mortality or symptomatic intracerebral haemorrhage. The trial was transformative because it showed that modern endovascular treatment using retrievable stents could improve patient outcomes when added to standard medical therapy. For HCPs, MR CLEAN also highlights the importance of patient selection and workflow: vascular imaging should identify eligible large-vessel occlusion quickly, and treatment should be delivered without unnecessary delay. The study provides the foundation for the larger evidence base that later extended thrombectomy into the late window and, more recently, into selected large-core strokes. Its relevance to IANCON's vascular neurology and thrombectomy sessions remains substantial.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
MR CLEAN was the pivotal randomized trial that established the efficacy of intra-arterial treatment for acute ischemic stroke caused by proximal anterior-circulation arterial occlusion. Five hundred patients were randomized to usual care with or without intravenous alteplase plus intra-arterial treatment. The intervention group had a better overall distribution of functional outcomes at 90 days, with a clinically important increase in functional independence. There was no significant increase in mortality or symptomatic intracerebral haemorrhage. The trial was transformative because it showed that modern endovascular treatment using retrievable stents could improve patient outcomes when added to standard medical therapy. For HCPs, MR CLEAN also highlights the importance of patient selection and workflow: vascular imaging should identify eligible large-vessel occlusion quickly, and treatment should be delivered without unnecessary delay. The study provides the foundation for the larger evidence base that later extended thrombectomy into the late window and, more recently, into selected large-core strokes. Its relevance to IANCON's vascular neurology and thrombectomy sessions remains substantial.
4 weeks back
A bioengineered oral nanozyme microsupplement converts pathological ROS into a protective polydopamine hydrogel shield. By curbing neutrophil extracellular traps and balancing T cells, this platform outperforms standard 5-ASA in preclinical colitis models, opening new paths for sustained remission.
4 days back
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
4 weeks back
Abdominal aortic aneurysm rupture remains a catastrophic vascular emergency. Groundbreaking research reveals that USP53 accelerates aneurysm progression by reprogramming smooth muscle cell metabolism toward aerobic glycolysis, highlighting a promising target beyond conventional diameter-based surveillance.
5 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
4 days back
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
5 days back
