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The LACC randomized trial compared minimally invasive radical hysterectomy with open abdominal radical hysterectomy in women with early-stage cervical cancer. Minimally invasive surgery was associated with lower disease-free and overall survival than open surgery in the trial population, leading to major changes in surgical practice. The finding is crucial for gynecologic oncology because it demonstrates that better perioperative recovery does not automatically translate into equivalent oncologic outcomes. For clinicians, route of surgery must therefore be evaluated in terms of cancer control, not only blood loss and length of stay. Patient counseling should explain the evidence, while tumor characteristics, surgical expertise and evolving guideline recommendations inform the final decision. The trial is a cornerstone example of why randomized evidence matters when new technology enters cancer surgery.
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The LACC randomized trial compared minimally invasive radical hysterectomy with open abdominal radical hysterectomy in women with early-stage cervical cancer. Minimally invasive surgery was associated with lower disease-free and overall survival than open surgery in the trial population, leading to major changes in surgical practice. The finding is crucial for gynecologic oncology because it demonstrates that better perioperative recovery does not automatically translate into equivalent oncologic outcomes. For clinicians, route of surgery must therefore be evaluated in terms of cancer control, not only blood loss and length of stay. Patient counseling should explain the evidence, while tumor characteristics, surgical expertise and evolving guideline recommendations inform the final decision. The trial is a cornerstone example of why randomized evidence matters when new technology enters cancer surgery.
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