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This pilot trial evaluated the safety and efficacy of low-intensity focused ultrasound (LIFU) targeting the seizure onset zone in 12 patients with drug-resistant epilepsy. During the randomized crossover phase, LIFU did not significantly reduce seizure frequency compared with sham stimulation (estimate 0.49; 95% CI −0.04 to 1.01; P=.068). However, during open-label follow-up, seizure frequency declined significantly by 14.0 percentage points per month (95% CI −22.2 to −5.8; P=.001). MRI showed no structural lesions, and no serious adverse events occurred. Anxiety, depression, and quality-of-life scores did not significantly change. The authors note that larger, longer parallel-group trials are needed to establish efficacy.
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This pilot trial evaluated the safety and efficacy of low-intensity focused ultrasound (LIFU) targeting the seizure onset zone in 12 patients with drug-resistant epilepsy. During the randomized crossover phase, LIFU did not significantly reduce seizure frequency compared with sham stimulation (estimate 0.49; 95% CI −0.04 to 1.01; P=.068). However, during open-label follow-up, seizure frequency declined significantly by 14.0 percentage points per month (95% CI −22.2 to −5.8; P=.001). MRI showed no structural lesions, and no serious adverse events occurred. Anxiety, depression, and quality-of-life scores did not significantly change. The authors note that larger, longer parallel-group trials are needed to establish efficacy.
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