.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Intra-arterial chemotherapy has transformed the management of advanced retinoblastoma by delivering chemotherapy directly through the ophthalmic artery. A large retrospective series evaluated 341 eyes treated with more than 1,200 infusions and examined tumour control and globe salvage across disease groups and patient characteristics. Five-year globe salvage was approximately 74% overall, although outcomes varied substantially by tumour stage. The study supports IAC as an important globe-preserving approach when delivered in experienced centres. At the same time, it is observational and therefore cannot establish comparative superiority over systemic or other focal treatment strategies. For HCPs, the key message is that globe salvage is not synonymous with useful vision. Treatment planning should consider tumour control, retinal and optic-nerve preservation, visual potential and long-term follow-up. The evidence aligns closely with AIOC's retinoblastoma globe-salvage theme within oculoplasty and paediatric ophthalmology.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
Intra-arterial chemotherapy has transformed the management of advanced retinoblastoma by delivering chemotherapy directly through the ophthalmic artery. A large retrospective series evaluated 341 eyes treated with more than 1,200 infusions and examined tumour control and globe salvage across disease groups and patient characteristics. Five-year globe salvage was approximately 74% overall, although outcomes varied substantially by tumour stage. The study supports IAC as an important globe-preserving approach when delivered in experienced centres. At the same time, it is observational and therefore cannot establish comparative superiority over systemic or other focal treatment strategies. For HCPs, the key message is that globe salvage is not synonymous with useful vision. Treatment planning should consider tumour control, retinal and optic-nerve preservation, visual potential and long-term follow-up. The evidence aligns closely with AIOC's retinoblastoma globe-salvage theme within oculoplasty and paediatric ophthalmology.
Today
The phase 3 ACACIA-HCM trial reveals that aficamten improves cardiac structure, diastolic relaxation, functional capacity, and symptom burden in symptomatic nonobstructive hypertrophic cardiomyopathy, marking a major milestone in targeted myosin inhibition.
6 days back
A clinical study shows that automated breast ultrasound paired with artificial intelligence accurately classifies BIRADS 3-4 lesions, reaching 95% sensitivity and 79% specificity. This diagnostic advance promises to reduce unnecessary core needle biopsies and refine clinical workflows in breast imaging.
3 weeks back
Researchers have engineered freestanding hierarchical-porous BCZT thin films that resist cracking and enhance ultrasonic energy harvesting in soft tissue. Achieving high piezoelectric output and acoustic matching, this lead-free material offers transformative potential for implantable bioelectronics.
6 days back
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
3 weeks back
A breakthrough study identifies the Klotho/PKCα/CUX1/SPARC/TGFβ-RII axis as a critical driver of podocyte mitochondrial injury and ferroptosis in diabetic kidney disease, unveiling promising molecular targets to halt renal disease progression.
6 days back
