.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Adolescent idiopathic scoliosis can progress during growth, with larger curves creating a greater risk of surgery. The multicentre BRAIST trial compared bracing with observation in adolescents who met accepted criteria for a high risk of curve progression. The randomized component was stopped early because the efficacy signal favoured bracing. Across the combined randomized and preference cohorts, bracing substantially increased the probability of treatment success, defined as reaching skeletal maturity without progression to a curve magnitude associated with surgery. The benefit was related to the number of hours the brace was worn. For HCPs, the study established that bracing is an effective strategy for appropriately selected skeletally immature adolescents rather than a low-value holding measure. Adherence is central, and counselling should address comfort, body image, school activities and practical barriers. The trial also illustrates why early recognition matters: bracing is intended to prevent progression while substantial growth remains, not to reverse a mature deformity. Shared decision-making should integrate curve magnitude, skeletal maturity, expected progression risk and patient preferences.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
Adolescent idiopathic scoliosis can progress during growth, with larger curves creating a greater risk of surgery. The multicentre BRAIST trial compared bracing with observation in adolescents who met accepted criteria for a high risk of curve progression. The randomized component was stopped early because the efficacy signal favoured bracing. Across the combined randomized and preference cohorts, bracing substantially increased the probability of treatment success, defined as reaching skeletal maturity without progression to a curve magnitude associated with surgery. The benefit was related to the number of hours the brace was worn. For HCPs, the study established that bracing is an effective strategy for appropriately selected skeletally immature adolescents rather than a low-value holding measure. Adherence is central, and counselling should address comfort, body image, school activities and practical barriers. The trial also illustrates why early recognition matters: bracing is intended to prevent progression while substantial growth remains, not to reverse a mature deformity. Shared decision-making should integrate curve magnitude, skeletal maturity, expected progression risk and patient preferences.
Today
The phase 3 ACACIA-HCM trial reveals that aficamten improves cardiac structure, diastolic relaxation, functional capacity, and symptom burden in symptomatic nonobstructive hypertrophic cardiomyopathy, marking a major milestone in targeted myosin inhibition.
6 days back
A clinical study shows that automated breast ultrasound paired with artificial intelligence accurately classifies BIRADS 3-4 lesions, reaching 95% sensitivity and 79% specificity. This diagnostic advance promises to reduce unnecessary core needle biopsies and refine clinical workflows in breast imaging.
3 weeks back
Researchers have engineered freestanding hierarchical-porous BCZT thin films that resist cracking and enhance ultrasonic energy harvesting in soft tissue. Achieving high piezoelectric output and acoustic matching, this lead-free material offers transformative potential for implantable bioelectronics.
6 days back
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
3 weeks back
A breakthrough study identifies the Klotho/PKCα/CUX1/SPARC/TGFβ-RII axis as a critical driver of podocyte mitochondrial injury and ferroptosis in diabetic kidney disease, unveiling promising molecular targets to halt renal disease progression.
6 days back
