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The ICON7 trial evaluated bevacizumab added to standard platinum-based chemotherapy and maintenance treatment in women with newly diagnosed epithelial ovarian cancer. The addition improved progression-free survival overall, with a larger effect in patients at high risk of progression. The study helped establish anti-angiogenic therapy as one component of advanced ovarian-cancer management. For gynecologic oncologists, the result illustrates how treatment intensity should be matched to disease-risk phenotype. Bevacizumab requires monitoring for hypertension, proteinuria, thrombotic complications, impaired wound healing and gastrointestinal toxicity. Its benefit must therefore be considered alongside surgical timing and overall patient fitness.
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The ICON7 trial evaluated bevacizumab added to standard platinum-based chemotherapy and maintenance treatment in women with newly diagnosed epithelial ovarian cancer. The addition improved progression-free survival overall, with a larger effect in patients at high risk of progression. The study helped establish anti-angiogenic therapy as one component of advanced ovarian-cancer management. For gynecologic oncologists, the result illustrates how treatment intensity should be matched to disease-risk phenotype. Bevacizumab requires monitoring for hypertension, proteinuria, thrombotic complications, impaired wound healing and gastrointestinal toxicity. Its benefit must therefore be considered alongside surgical timing and overall patient fitness.
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