.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
The BaSICS randomised clinical trial compared a balanced crystalloid solution with 0.9% saline in critically ill adults. More than 5,000 patients across Brazilian ICUs were randomised, making the trial one of several major studies examining whether fluid composition influences kidney outcomes and survival. The trial did not show a mortality advantage for balanced solution over saline in the overall population. That finding is important because physiological concerns about chloride load and kidney injury do not automatically translate into a large survival effect in every critically ill patient. For clinicians, the study should be interpreted alongside other large fluid trials rather than in isolation. Patient characteristics, type of shock, renal function, cumulative fluid exposure and the indication for each fluid bolus all influence the risk-benefit balance. This fits CritiCARE's sessions on fluid management, shock, AKI and personalised resuscitation. The practical shift is away from asking “Which fluid is best?” as a standalone question and toward asking “Does this patient need fluid now, which fluid is appropriate, and how will I know when to stop?” BaSICS therefore supports a broader concept of fluid stewardship: fluid is a drug, and both composition and cumulative exposure deserve deliberate prescribing.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
The BaSICS randomised clinical trial compared a balanced crystalloid solution with 0.9% saline in critically ill adults. More than 5,000 patients across Brazilian ICUs were randomised, making the trial one of several major studies examining whether fluid composition influences kidney outcomes and survival. The trial did not show a mortality advantage for balanced solution over saline in the overall population. That finding is important because physiological concerns about chloride load and kidney injury do not automatically translate into a large survival effect in every critically ill patient. For clinicians, the study should be interpreted alongside other large fluid trials rather than in isolation. Patient characteristics, type of shock, renal function, cumulative fluid exposure and the indication for each fluid bolus all influence the risk-benefit balance. This fits CritiCARE's sessions on fluid management, shock, AKI and personalised resuscitation. The practical shift is away from asking “Which fluid is best?” as a standalone question and toward asking “Does this patient need fluid now, which fluid is appropriate, and how will I know when to stop?” BaSICS therefore supports a broader concept of fluid stewardship: fluid is a drug, and both composition and cumulative exposure deserve deliberate prescribing.
4 weeks back
A bioengineered oral nanozyme microsupplement converts pathological ROS into a protective polydopamine hydrogel shield. By curbing neutrophil extracellular traps and balancing T cells, this platform outperforms standard 5-ASA in preclinical colitis models, opening new paths for sustained remission.
3 days back
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
4 weeks back
Abdominal aortic aneurysm rupture remains a catastrophic vascular emergency. Groundbreaking research reveals that USP53 accelerates aneurysm progression by reprogramming smooth muscle cell metabolism toward aerobic glycolysis, highlighting a promising target beyond conventional diameter-based surveillance.
4 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
4 days back
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
5 days back
