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Experts analyzed 407 HR+/HER2- advanced breast cancer (aBC) patients after CDK4/6 inhibitor (CDK4/6i) failure. Median time to next treatment (mTTNT) was 26 months for first-line CDK4/6i. For subsequent second-line therapies, chemotherapy showed the longest mTTNT (24 months) compared to CDK4/6i-based regimens (15 months) or everolimus ± ET (9.6 months). Number of disease sites predicted longer first-line TTNT.

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Experts analyzed 407 HR+/HER2- advanced breast cancer (aBC) patients after CDK4/6 inhibitor (CDK4/6i) failure. Median time to next treatment (mTTNT) was 26 months for first-line CDK4/6i. For subsequent second-line therapies, chemotherapy showed the longest mTTNT (24 months) compared to CDK4/6i-based regimens (15 months) or everolimus ± ET (9.6 months). Number of disease sites predicted longer first-line TTNT.
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