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This double-blind, placebo-controlled phase 2b trial (A-HACK) randomized 120 adults with alcohol use disorder who binge drank at least weekly to a standardized kudzu extract (2 g) or placebo for 12 weeks, taken at least 2.5 hours before anticipated heavy drinking; both groups received brief weekly counseling. Binge drinking was defined as ≥5 drinks per occasion for men and ≥4 for women. In the intention-to-treat analysis, kudzu reduced binge-drinking days by 27% relative to placebo; average weekly binge-drinking days fell from 2.15 to 1.42 with kudzu versus 2.15 to 2.06 with placebo. The proportion of weeks with any binge drinking declined from 88% to 58% with kudzu compared with 88% to 81% with placebo, and the likelihood of a binge-drinking week was 21% lower. Three months after treatment ended, the kudzu group still reported 32% fewer binge-drinking days than placebo. The authors concluded that targeted kudzu reduced binge drinking among adults with alcohol use disorder and that larger studies are needed to confirm the findings in broader populations.
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This double-blind, placebo-controlled phase 2b trial (A-HACK) randomized 120 adults with alcohol use disorder who binge drank at least weekly to a standardized kudzu extract (2 g) or placebo for 12 weeks, taken at least 2.5 hours before anticipated heavy drinking; both groups received brief weekly counseling. Binge drinking was defined as ≥5 drinks per occasion for men and ≥4 for women. In the intention-to-treat analysis, kudzu reduced binge-drinking days by 27% relative to placebo; average weekly binge-drinking days fell from 2.15 to 1.42 with kudzu versus 2.15 to 2.06 with placebo. The proportion of weeks with any binge drinking declined from 88% to 58% with kudzu compared with 88% to 81% with placebo, and the likelihood of a binge-drinking week was 21% lower. Three months after treatment ended, the kudzu group still reported 32% fewer binge-drinking days than placebo. The authors concluded that targeted kudzu reduced binge drinking among adults with alcohol use disorder and that larger studies are needed to confirm the findings in broader populations.
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