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In this retrospective study of 105 patients with HER2-positive metastatic breast cancer, 24 received at least two HER2-targeted tyrosine kinase inhibitor (TKI) regimens. Of these, 58% remained on a subsequent TKI for over six months, and 42% had longer treatment durations on later regimens. These findings support the sequential use of HER2-targeted TKIs as a viable strategy, even after prior TKI exposure.
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In this retrospective study of 105 patients with HER2-positive metastatic breast cancer, 24 received at least two HER2-targeted tyrosine kinase inhibitor (TKI) regimens. Of these, 58% remained on a subsequent TKI for over six months, and 42% had longer treatment durations on later regimens. These findings support the sequential use of HER2-targeted TKIs as a viable strategy, even after prior TKI exposure.
Today
The Democratic Republic of Congo is facing a severe epidemic driven by the Bundibugyo virus, with over 3,000 confirmed cases and 1,350 deaths across five provinces. While existing Ebola vaccines target the Zaire strain, clinical trials for a new candidate from Oxford University have urgently commenced.
Yesterday
A comprehensive analysis of the NFHS-5 data regarding postpartum anemia in India, exploring the prevalence, severity, and the socioeconomic and regional factors contributing to this public health challenge for clinicians seeking to improve maternal health outcomes.
Last week
A study in Greece reveals that 46-80% of heatwave deaths are linked to climate change. This analysis explores the implications for public health and clinical practice, particularly for elderly and vulnerable populations facing rising global temperatures in regions like India.
2 weeks back
Nearly 80% of Indians suffer from inadequate Vitamin D, causing silent bone weakening and sudden fractures. This expert guide reviews why mega-dose therapy is critical for high-risk patients, the key factors driving widespread deficiency, and the mandatory medical evaluations needed to protect skeletal health.
last month
With World Obesity Atlas data warning that over 41 million Indian children are overweight or obese, ICMR and NIN have unveiled a 10-point policy roadmap. The initiative calls for mandatory front-of-pack labeling, HFSS taxes, strict marketing bans, and healthier school environments to curb non-communicable diseases.
Yesterday
