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Meta-analysis determined whether a biopsy from D1 alone can enhance celiac disease diagnosis in 16 studies. Diagnostic rate from D1 & D2 biopsy were 77.4% & 75.3%, respectively. D1 biopsy increased diagnostic yield by 6.9%. Using 2 biopsy samples, diagnostic rates were 77.3% from D1 & 86.4% from D2. With 4 biopsy samples, rates were 83.3% from D1 & 70.5% from D2, with no significant difference. Thus, obtaining 4 samples added no benefit.
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Meta-analysis determined whether a biopsy from D1 alone can enhance celiac disease diagnosis in 16 studies. Diagnostic rate from D1 & D2 biopsy were 77.4% & 75.3%, respectively. D1 biopsy increased diagnostic yield by 6.9%. Using 2 biopsy samples, diagnostic rates were 77.3% from D1 & 86.4% from D2. With 4 biopsy samples, rates were 83.3% from D1 & 70.5% from D2, with no significant difference. Thus, obtaining 4 samples added no benefit.
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