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This Indian multicentre trial randomized 500 adults undergoing elective brain-tumour craniotomy to fentanyl (n = 252) or dexmedetomidine (n = 248). Rescue fentanyl requirements did not differ significantly (38.0 vs 44.6 μg; P = 0.327), nor did moderate-to-severe recovery-room pain (60.0% vs 59.2%; P = 0.559). Intraoperative hypotension was more frequent with dexmedetomidine (100/248 vs 75/252; P = 0.015), while shivering was less frequent (9/241 vs 22/251; P = 0.026). Other outcomes were similar. Conclusion: Opioid-sparing dexmedetomidine provided comparable analgesia but increased intraoperative hypotension.
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This Indian multicentre trial randomized 500 adults undergoing elective brain-tumour craniotomy to fentanyl (n = 252) or dexmedetomidine (n = 248). Rescue fentanyl requirements did not differ significantly (38.0 vs 44.6 μg; P = 0.327), nor did moderate-to-severe recovery-room pain (60.0% vs 59.2%; P = 0.559). Intraoperative hypotension was more frequent with dexmedetomidine (100/248 vs 75/252; P = 0.015), while shivering was less frequent (9/241 vs 22/251; P = 0.026). Other outcomes were similar. Conclusion: Opioid-sparing dexmedetomidine provided comparable analgesia but increased intraoperative hypotension.
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