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SBMA is an X-linked motor neuron disease caused by a defect in the androgen receptor gene. It primarily affects males and leads to progressive muscle weakness.
AI-assisted MRI analysis provides an objective and precise measurement of muscle loss. This automated method reduces human error and allows for better tracking of disease progression over time.
Yes, tongue atrophy is a hallmark sign of SBMA. It can occur early in the disease, sometimes before severe speech or swallowing difficulties become apparent.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis or treatment. Refer to the latest local and national guidelines for clinical practice.
References
Rosenbohm A et al. Tongue volume in spinal and bulbar muscular atrophy (SBMA): an AI-assisted automatic MRI analysis. J Neurol. 2026 Jun 07. doi: undefined. PMID: 42251620.
Atsuta N, et al. Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients. Brain. 2006;129(6):1446-1455.
Rhodes FB, et al. Spinal and bulbar muscular atrophy: pathogenesis and clinical management. J Mol Neurosci. 2009;39(1-2):156-160.
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This study highlights how AI-driven MRI segmentation provides objective quantification of tongue atrophy in spinal and bulbar muscular atrophy (SBMA) patien...
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