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Natural products remain indispensable for modern medicine and human nutrition. Therefore, researchers continuously seek more effective ways to profile plant metabolites. Phytometabolomics has recently gained significant momentum due to rapid improvements in mass spectrometry. However, traditional organic solvents often pose safety and efficiency challenges. Consequently, scientists are adopting NADES green extraction media to enhance the recovery and stability of natural compounds.
These natural solvents consist of simple metabolites such as sugars, amino acids, and organic acids. Moreover, they offer a tunable composition that allows researchers to target specific bioactives. Scientists prefer these solvents because they are biodegradable and exhibit low toxicity. Furthermore, they stabilize labile compounds better than conventional organic solvents. Consequently, they provide a promising strategy for sustainable pharmaceutical and food research. In addition, the use of these green media aligns with global efforts to reduce chemical waste in laboratories.
Despite these clear benefits, some technical limitations exist. Specifically, high viscosity can occasionally hinder large-scale industrial application. Additionally, the standardization of NADES compositions remains a primary concern for regulatory compliance. However, ongoing studies aim to optimize these green solvents for wider clinical and industrial use in India and abroad.
Natural Deep Eutectic Solvents typically consist of natural metabolites such as sugars, amino acids, and organic acids. These components interact to create a liquid phase with unique extraction properties.
These solvents form strong hydrogen bonds with plant metabolites. Therefore, they protect sensitive compounds from thermal or chemical degradation during the extraction process.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or professional consultation. Refer to the latest local and national guidelines for clinical practice.
References
Singh IP et al. Natural Deep Eutectic Solvents as Green Extraction Media for Nutritional and Functional Bioactives. J Agric Food Chem. 2026 May 06. doi: 10.1021/acs.jafc.6c00066. PMID: 42090186.
Shikov AN et al. Natural Deep Eutectic Solvents: Green Chemistry Solutions for Pharmaceutical Applications. Molecules. 2020;25(7):1619.
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NADES offer a sustainable and efficient alternative to traditional solvents for extracting plant bioactives, enhancing stability and reducing toxicity....
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