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Researchers evaluated 40 patients with metaplastic breast carcinoma (MpBC) treated with neoadjuvant chemotherapy (NAC), with or without immune checkpoint inhibitors (ICIs). While only 6% of patients receiving NAC alone achieved pathologic complete response (pCR), 67% of those starting immunotherapy concurrently with NAC achieved pCR. These findings suggest that adding ICIs to NAC may significantly enhance treatment response in MpBC.
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Researchers evaluated 40 patients with metaplastic breast carcinoma (MpBC) treated with neoadjuvant chemotherapy (NAC), with or without immune checkpoint inhibitors (ICIs). While only 6% of patients receiving NAC alone achieved pathologic complete response (pCR), 67% of those starting immunotherapy concurrently with NAC achieved pCR. These findings suggest that adding ICIs to NAC may significantly enhance treatment response in MpBC.
2 months ago
As monsoon seasons elevate arboviral disease threats, Tamil Nadu has initiated an ICMR-monitored evaluation of the tetravalent dengue vaccine in Tenkasi district. Clinicians emphasize clinical monitoring, public prevention, and high-quality early pediatric care to reduce disease morbidity across endemic regions.
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A comparative cohort study evaluates vNOTES vs TLH hysterectomy for benign conditions, demonstrating shorter operative duration, faster return to daily activities, and equivalent female sexual function scores without increased dyspareunia.
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Review how tailored exercise programs benefit frail older patients with heart failure. Explore pathophysiological mechanisms, individualized training prescriptions, and strategies to overcome adherence barriers in clinical practice.
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This comparative study evaluates posterior labral tears with and without glenohumeral instability, highlighting distinct demographic patterns, MRI underestimation in stable shoulders, and successful arthroscopic repair outcomes.
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A clinical study demonstrates that early intervention with tocilizumab, either as monotherapy or bridged with corticosteroids, achieves significant proptosis reduction and resolves active inflammation in treatment-naive thyroid eye disease.
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