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Experts analyzed 2,098 patients with early-stage ER+ HER2− invasive lobular carcinoma (ILC) to examine the prevalence and prognostic relevance of HER2-low status. HER2-low tumors were found in 52.6% of patients and were associated with larger tumor size and multifocality. Compared to HER2 0, HER2-low status was independently associated with worse disease-free survival and overall survival, but not with distant recurrence-free survival.

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Experts analyzed 2,098 patients with early-stage ER+ HER2− invasive lobular carcinoma (ILC) to examine the prevalence and prognostic relevance of HER2-low status. HER2-low tumors were found in 52.6% of patients and were associated with larger tumor size and multifocality. Compared to HER2 0, HER2-low status was independently associated with worse disease-free survival and overall survival, but not with distant recurrence-free survival.
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