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Experts analyzed 2,098 patients with early-stage ER+ HER2− invasive lobular carcinoma (ILC) to examine the prevalence and prognostic relevance of HER2-low status. HER2-low tumors were found in 52.6% of patients and were associated with larger tumor size and multifocality. Compared to HER2 0, HER2-low status was independently associated with worse disease-free survival and overall survival, but not with distant recurrence-free survival.
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Experts analyzed 2,098 patients with early-stage ER+ HER2− invasive lobular carcinoma (ILC) to examine the prevalence and prognostic relevance of HER2-low status. HER2-low tumors were found in 52.6% of patients and were associated with larger tumor size and multifocality. Compared to HER2 0, HER2-low status was independently associated with worse disease-free survival and overall survival, but not with distant recurrence-free survival.
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Co-administering antiseizure medications and DOACs frequently causes pharmacokinetic interactions, subtherapeutic drug levels, and thromboembolic failures. This review highlights enzyme induction risks, unpredictable outcomes with levetiracetam, and the vital role of therapeutic drug monitoring.
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Demanding exhaustive hormonal profiling can inadvertently discourage clinical studies involving females. Methodological standards must align with the specific scientific question to expand, not restrict, equitable evidence for women.
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A comparative review of tension band wiring and intramedullary screw fixation in thumb metacarpophalangeal arthrodesis, evaluating union rates, hardware complications, and clinical outcomes.
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Following regulatory scrutiny from FSSAI regarding promotional representations and lean muscle preservation claims, Dr. Reddy's Laboratories and Nestlé Health Science are currently reviewing the branding and marketing strategy for their joint nutritional supplement Celevida GLP+.
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