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Experts examined 8,047 T2D patients and found fenofibrate's benefit on sight-threatening diabetic retinopathy (STDR) was greatest in those with the lowest baseline haptoglobin (HP) levels. Fenofibrate reduced HP levels, but phenotype or change in HP did not significantly impact STDR benefit. Low baseline HP may indicate greater susceptibility to retinal oxidative injury. All HP phenotypes benefited from fenofibrate.
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Experts examined 8,047 T2D patients and found fenofibrate's benefit on sight-threatening diabetic retinopathy (STDR) was greatest in those with the lowest baseline haptoglobin (HP) levels. Fenofibrate reduced HP levels, but phenotype or change in HP did not significantly impact STDR benefit. Low baseline HP may indicate greater susceptibility to retinal oxidative injury. All HP phenotypes benefited from fenofibrate.
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