Novel glucose-responsive mPEG-PSA nanocarriers deliver insulin aspart on demand, achieving dual postprandial and basal glycemic control without hypoglycemia in diabetic models. This biomaterial breakthrough offers promising clinical implications for physiologic diabetes management.

A novel folate-conjugated tecto-dendrimer nanoplatform successfully delivers siRNA to achieve targeted HK2 silencing, disrupting ovarian cancer glycolysis and suppressing lactate output.

A comparative non-contact study reveals that high-power radiofrequency delivery with the QDOT MICRO catheter induces an artifactual contact force rise. Electrophysiologists must understand this power-dependent thermal and electrical phenomenon to avoid inadvertent catheter withdrawal and ineffective ablation.

A novel proof-of-concept study presents a six-degree-of-freedom articulated manikin neck equipped with linear potentiometers. The system provides real-time kinematic motion feedback during cervical immobilisation, delivering sub-degree tracking accuracy to improve pre-hospital trauma training and patient safety.

A retrospective comparative cohort study evaluated genitourinary safety in HFpEF between dapagliflozin and empagliflozin over six months. Rates of symptomatic UTI and asymptomatic bacteriuria showed no statistically significant differences, supporting comparable safety profiles across both SGLT2 inhibitors.