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A breakthrough study reveals that digoxin alleviates osteoarthritis by targeting LSP1 in synovial macrophages, preventing harmful extracellular trap formation and restoring SOD1 activity. This dual-action mechanism protects joint cartilage and offers a promising repurposing strategy for disease modification.
A pharmacovigilance analysis of over 357,000 FAERS reports evaluates infection risks across systemic psoriasis therapies. While IL-23 inhibitors showed near-null signals, IL-17 and IL-12/23 inhibitors maintained elevated infection reporting, with IL-17 agents demonstrating a notable signal for candidiasis.
A recent preclinical study reveals that regulatory T cell therapy effectively cures chronic dermatitis but shows limited efficacy in chronic arthritis, driven by distinct tissue microenvironments and molecular pathway responses.
A retrospective analysis reveals an average EGPA diagnostic delay of 4.8 years. Female sex and prior biologic use increase delay risk, whereas ANCA positivity and renal involvement accelerate diagnosis. Multidisciplinary vigilance across pulmonology, ENT, and rheumatology is vital for earlier detection.
CT-guided pulsed radiofrequency ablation of the obturator nerve delivers durable pain relief up to 12 months in mild-to-moderate hip osteoarthritis, while offering a safe short-term palliative bridge for severe grade 4 disease without procedural complications.
