This expert review examines the critical role of SLC25A51 as a mitochondrial NAD+ transporter in Acute Myeloid Leukemia (AML). It details the protein's impact on metabolic reprogramming, its prognostic significance, and emerging therapeutic strategies involving combinations with hypomethylating agents.

A study identifies a critical hypospadias gene-environment interaction. Research shows that the risk gene DNAH8 and DEHP exposure combine to disrupt steroidogenesis and mesenchymal progenitor cell differentiation, significantly increasing the risk of severe urethral malformations in male fetuses.

Discover how a multi-modal variational autoencoder uses video and pose data to detect coronary angiography workflow anomalies, improving cath lab efficiency.

Discover how biophysical forces shape tissue formation and regeneration. This review explores mechanotransduction in tissue development, from molecular sensors like integrins to tissue-scale flows, highlighting critical implications for regenerative medicine and functional organoid engineering.

A groundbreaking study utilizes single-cell RNA sequencing to map the tumor microenvironment of ovarian steroid cell tumors-not otherwise specified (SCT-NOS), identifying key steroidogenic subtypes and immune cell distributions that drive hyperandrogenism and tumor progression.