.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
A pioneering study at H N Reliance Hospital in Mumbai suggests that a nasal anesthetic spray can significantly reduce pre-operative anxiety. This intranasal delivery system offers a non-invasive alternative to traditional intravenous (IV) sedation for adults undergoing specific medical procedures. Specifically, the trial focused on patients scheduled for gastrointestinal endoscopy between July 2023 and June 2024.
The modified spray contains a combination of ketamine, midazolam, and lignocaine. These agents work together to sedate patients while simultaneously managing pain. According to the study authors, the intranasal drug delivery system achieved superior pain control compared to standard IV sedation. Furthermore, patients reported higher mobility and lower post-operative anxiety levels. Consequently, this method helps patients enter a trance-like sleep from which they can easily awaken when spoken to by staff.
While the nasal anesthetic spray provides convenience, experts note it may not replace IV sedation for all surgeries. For instance, Dr. Ashish Mali from Nair Hospital mentioned that sedation dosages depend heavily on the surgical complexity. If a patient\'s blood pressure drops during a procedure, an existing IV line remains the preferred route for emergency intervention. Therefore, this spray is most suitable for dentistry, pediatric cases, and non-invasive procedures like MRIs or endoscopies. Additionally, the spray eliminates the common fear of needles associated with IV medications.
Q1: What medications are included in the nasal spray?
The spray utilizes a combination of ketamine, midazolam, and lignocaine to provide sedation and pain relief.
Q2: Is this spray suitable for all types of surgery?
No, it is currently recommended for non-invasive procedures like endoscopies, MRIs, and dental work rather than complex, high-risk surgeries.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or replace professional judgment. Refer to the latest local and national guidelines for clinical practice.
References
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
Study reveals a nasal spray with ketamine and midazolam effectively reduces surgical anxiety and pain in endoscopy patients compared to IV sedation....
7 months ago
As monsoon seasons elevate arboviral disease threats, Tamil Nadu has initiated an ICMR-monitored evaluation of the tetravalent dengue vaccine in Tenkasi district. Clinicians emphasize clinical monitoring, public prevention, and high-quality early pediatric care to reduce disease morbidity across endemic regions.
Today
Leucine Rich Bio has introduced South Asia's first comprehensive vaginal microbiome test, BugSpeaks. By profiling microbial dysbiosis, pathogens, and antimicrobial resistance, this next-generation diagnostic platform provides clinicians with deeper insights into recurrent infections, fertility, and reproductive health.
Today
Review how tailored exercise programs benefit frail older patients with heart failure. Explore pathophysiological mechanisms, individualized training prescriptions, and strategies to overcome adherence barriers in clinical practice.
Today
This comparative study evaluates posterior labral tears with and without glenohumeral instability, highlighting distinct demographic patterns, MRI underestimation in stable shoulders, and successful arthroscopic repair outcomes.
Today
A clinical study demonstrates that early intervention with tocilizumab, either as monotherapy or bridged with corticosteroids, achieves significant proptosis reduction and resolves active inflammation in treatment-naive thyroid eye disease.
Today
