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"Wherever the art of Medicine is loved, there is also a love of Humanity."
— Hippocrates

No. Clinical studies indicate that intranasal insulin doses up to 160 IU do not significantly increase the risk of systemic hypoglycemia, as the delivery is primarily targeted to the brain.
The meta-analysis indicates significant risk reduction in patients undergoing cardiac, orthopedic, and gastrointestinal procedures, where delirium incidence is historically high.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or establish a doctor-patient relationship. Always seek the advice of a qualified healthcare provider for any medical condition or treatment. Refer to the latest local and national guidelines for clinical practice.
References
Desai A et al. Efficacy of intranasal insulin in reducing the incidence of postoperative delirium: A systematic review and meta-analysis of randomised controlled trials. J Perioper Pract. 2026 Feb 22. doi: 10.1177/17504589261421004. PMID: 41723589.
Zhang H et al. Intranasal insulin and postoperative delirium in adult surgical patients: a meta-analysis and systematic review of randomized controlled trials. Front Med (Lausanne). 2025 Nov 12;12:1670982. doi: 10.3389/fmed.2025.1670982.
Zhang Y et al. Effects of intranasal long-acting insulin pretreatment on postoperative delirium and the NLRP3/caspase-1/IL-1β pathway in older patients with esophageal cancer. Sciety. 2025. url: https://sciety.org/articles/10.1101/2024.12.30.24319458.
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